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- Title
Prevención de la mucositis oral secundaria a los tratamientos antineoplásicos en el cáncer de cabeza y cuello mediante suplemento con glutamina oral.
- Authors
Pachón Ibáñez, Jerónimo; Pereira Cunill, José Luis; Osorio Gómez, Giovana Fernanda; Irles Rocamora, Jose Antonio; Serrano Aguayo, Pilar; Quintana Ángel, Begoña; Fuentes Pradera, José; Chaves Conde, Manuel; Ortiz Gordillo, María José; García Luna, Pedro Pablo; Osorio Gómez, Guiovana Fernanda
- Abstract
<bold>Objectives: </bold>to evaluate the efficacy of glutamine in the prevention of the incidence of oral mucositis secondary to cancer therapies in patients with head and neck cancer (HNC). Secondary objectives were to know the incidence of odynophagia, interruptions of treatment and the requirements of analgesia and nasogastric tube.<bold>Material and Methods: </bold>prospective cohort study of patients with squamous cell carcinoma of HNC treated with radiotherapy ± concomitant chemotherapy. We compared 131 patients receiving glutamine orally at a dose of 10 g/8 hours with 131 patients who did not receive it.<bold>Results: </bold>patients not taking glutamine had a hazard ratio 1.78 times higher of mucositis (95% CI [1.01-3.16], p = 0.047). Regarding odynophagia, patients not taking glutamine had a hazard ratio 2.87 times higher (95% CI [1.62-5.18], p = 0.0003). The 19.8% of patients who did not take glutamine discontinued treatment versus6.9% of patients who took (p = 0.002). Regarding support requirements, 87.8% of patients without glutamine required analgesia versus 77.9% of patients with glutamine (p = 0.03) and nasogastric tube was indicated in 9.9% and 3.1% respectively (p = 0.02).<bold>Conclusion: </bold>oral glutamine in patients receiving cancer treatments for HNC prevents the incidence of oral mucositis and odynophagia, and decreases treatment interruptions and the use of analgesia and nasogastric tube.
- Subjects
GLUTAMINE; MUCOSITIS; CANCER treatment; HEAD &; neck cancer; NASOENTERAL tubes; SQUAMOUS cell carcinoma; PREVENTION; PATIENTS; THERAPEUTICS; ANTINEOPLASTIC agents; DIETARY supplements; HEAD tumors; LONGITUDINAL method; NECK tumors; DISEASE incidence; STOMATITIS; DISEASE complications
- Publication
Nutrición Hospitalaria, 2018, Vol 35, Issue 2, p428
- ISSN
0212-1611
- Publication type
journal article
- DOI
10.20960/nh.1467