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- Title
A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response.
- Authors
Campanella, C.; Marino Gammazza, A.; Mularoni, L.; Cappello, F.; Zummo, G.; Di Felice, V.
- Abstract
Chlamydia trachomatis serovar D produces large quantities of HSP60-1 during infections, which accumulate inside the host cell inducing autoimmunity. We compare the aminoacid sequences of the human HSP60 with the bacterial counterpart to better elucidate how CTHSP60 may simulate HSP60 from human origin during infection and may induce an autoimmune response. As a result of the comparison we suggest several possible epitopes of the CTHSP60, which may induce autoimmunity.
- Subjects
CHLAMYDIA trachomatis; AUTOIMMUNITY; HUMAN immunogenetics; GENETICS; AMINO compounds
- Publication
International Journal of Immunogenetics, 2009, Vol 36, Issue 1, p73
- ISSN
1744-3121
- Publication type
Article
- DOI
10.1111/j.1744-313X.2008.00819.x