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- Title
Metabolic response of porcine colon explants to in vitro infection by Brachyspira hyodysenteriae: a leap into disease pathophysiology.
- Authors
Welle, Thijs; Hoekstra, Anna; Daemen, Ineke; Berkers, Celia; Costa, Matheus
- Abstract
Introduction: Swine dysentery caused by Brachyspira hyodysenteriae is a production limiting disease in pig farming. Currently antimicrobial therapy is the only treatment and control method available. Objective: The aim of this study was to characterize the metabolic response of porcine colon explants to infection by B. hyodysenteriae. Methods: Porcine colon explants exposed to B. hyodysenteriae were analyzed for histopathological, metabolic and pro-inflammatory gene expression changes. Results: Significant epithelial necrosis, increased levels of l-citrulline and IL-1α were observed on explants infected with B. hyodysenteriae. Conclusions: The spirochete induces necrosis in vitro likely through an inflammatory process mediated by IL-1α and NO.
- Subjects
TREPONEMA hyodysenteriae; METABOLIC regulation; SWINE dysentery; PATHOLOGICAL physiology; GENE expression; IN vitro studies
- Publication
Metabolomics, 2017, Vol 13, Issue 7, p1
- ISSN
1573-3882
- Publication type
Article
- DOI
10.1007/s11306-017-1219-6