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- Title
Concise strategy for diastereoselective annulation to afford fused [5:7] oxazepanone γ-lactams.
- Authors
Abdul Rashid, Fatin Nur Ain; Mohammat, Mohd Fazli; Mansor, Nurul Shulehaf; Shaameri, Zurina; Hamzah, Ahmad Sazali
- Abstract
A series of novel potentially biologically active fused [5:7] oxazepanone γ-lactams were synthesized and described. A series of functional group transformations, namely amination, syn-hydrogenation and intramolecular annulation reactions were used to obtain the [5:7] oxazepanone γ-lactams in reasonable yields. In the diastereoselective fused-annulation for the formation of the secondary ring, steric constrain and cisgeometrical configuration of C-3 and C-4 substituents were observed as the predetermined factors. These ring annulations were purposely constructed to suit the physicochemical enhancement of the biological activity of the title compounds via SAR study of γ-lactams.
- Subjects
ANNULATION; TRANSFORMATION groups; FUNCTIONAL groups; LACTAMS; AMINATION
- Publication
ARKIVOC: Online Journal of Organic Chemistry, 2021, Vol 2021, p1
- ISSN
1551-7004
- Publication type
Article
- DOI
10.24820/ark.5550190.p011.618