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- Title
Tectochrysin Attenuates Cisplatin-induced Hepatotoxicity by Restoring Biochemical, Inflammatory and Histological Profile in Rats.
- Authors
Ijaz, Muhammad Umar; Rafi, Zainab; Hamza, Ali; Tariq, Muhammad; Alkahtani, Saad; Alkahtane, Abdullah A.; Riaz, Mian Nadeem
- Abstract
Cisplatin is an efficacious anticancerous chemotherapeutic agent that is used to cure multiple types of malignancies. However, it has several hazardous effects on multiple organs, particularly liver. Tectochrysin is a naturally occurring flavonoid with extensive pharmacological properties. In this research, the potential antioxidant properties of tectochrysin against cisplatin-triggered oxidative stress in rats' hepatic tissues were investigated. 48 male albino rats were separated into 4 groups: control cisplatin (10 mg/kg), cisplatin + tectochrysin (10 mg/kg + 5 mg/kg), and tectochrysin (5 mg/kg). The trial executed for one month. The biochemical, inflammatory, histopathological and liver markers were evaluated. The results of the research suggested that cisplatin treatment remarkably lowered the activities of glutathione (GSH), superoxide dismutase (SOD), glutathione reductase (GSR), glutathione S-transferase (GST), glutathione peroxidase (GPx) as well as catalase (CAT) while escalated malondialdehyde (MDA) and reactive oxygen species (ROS) levels. Cisplatin administered rats exhibited significantly higher aspartate aminotransferase (AST), alanine aminotransferase (ALT) as well as alkaline phosphatase (ALP) levels. Furthermore, cisplatin administration significantly elevated the inflammatory indicators i.e., interleukin-1ß (IL-1ß), tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6) as well as nuclear factor kappa-B (NF-κB) and cyclooxygenase-2 (COX-2) activity along with histopathological impairments. Conversely, co-administration with tectochrysin effectively reversed the cisplatintriggered impairments and abnormalities in the hepatic tissue of rats. The current investigation demonstrated that tectochrysin lowered cisplatin-induced hepatotoxicity owing to its antioxidant, reactive oxygen species scavenging activities and anti-inflammatory effects.
- Subjects
CISPLATIN; METABOLIC detoxification; ASPARTATE aminotransferase; GLUTATHIONE reductase; HEPATOTOXICOLOGY; GLUTATHIONE peroxidase; REACTIVE oxygen species; SUPEROXIDE dismutase; ALANINE aminotransferase
- Publication
Pakistan Veterinary Journal, 2023, Vol 43, Issue 2, p366
- ISSN
0253-8318
- Publication type
Article
- DOI
10.29261/pakvetj/2023.029