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- Title
Antibacterial compound from the endophytic fungus Phomopsis longicolla isolated from the tropical red seaweed Bostrychia radicans.
- Authors
Erbert, Cíntia; Lopes, Adriana A.; Yokoya, Nair S.; Furtado, Niege A.J.C.; Conti, Raphael; Pupo, Mônica T.; Lopes, João Luis C.; Debonsi, Hosana M.
- Abstract
Endophytic fungi isolated from the red seaweed Bostrychia radicans were studied to identify their molecularly diverse and biologically active natural chemical products. According to 28S ribosomal DNA-based identification, the strain named C81 was 98% identical to Phomopsis longicolla. This strain was cultivated in solid rice medium and produced three major metabolites identified as 18-deoxycytochalasin H ( 1), mycophenolic acid ( 2), and dicerandrol C ( 3). The chemical structures of these compounds were elucidated by 1D and 2D nuclear magnetic resonance as well as by mass spectrometry. Dicerandrol C had significant antimicrobial activity against Staphylococcus aureus (ATCC 6538) and Staphylococcus saprophyticus (ATCC 15305), with minimum inhibitory concentrations of 1 and 2 μg ml-1(1.33 and 2.66 μ m), respectively. These results show the presence of promising metabolites and indicate that these natural products should be considered in the development of new antibiotics.
- Subjects
ANTIBACTERIAL agents; ENDOPHYTIC fungi; MARINE algae; RED algae; BOSTRYCHIA (Algae); IDENTIFICATION of fungi; BIOACTIVE compounds; RIBOSOMAL DNA
- Publication
Botanica Marina, 2012, Vol 55, Issue 4, p435
- ISSN
0006-8055
- Publication type
Article
- DOI
10.1515/bot-2011-0023