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- Title
Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP
- Authors
Chérasse, Yoan; Chaveroux, Cédric; Jousse, Céline; Maurin, Anne-Catherine; Carraro, Valérie; Parry, Laurent; Fafournoux, Pierre; Bruhat, Alain
- Abstract
Abstract: The transcriptional activation of CHOP (C/EBP-homologous protein) by amino acid deprivation involves ATF2 and ATF4 binding at the amino acid response element within the promoter. In this report, we investigate the role of JDP2 (Jun Dimerization Protein 2) in the amino acid control of CHOP transcription following amino acid starvation. Our results show that JDP2 binds to the CHOP AARE in unstimulated cells and that its binding decreases following amino acid starvation. We demonstrate that JDP2 acts as a repressor and suggest that it could be functionally associated with HDAC3 to inhibit CHOP transcription.
- Subjects
GENETIC repressors; GENETIC regulation; AMINO acids; CELLS
- Publication
FEBS Letters, 2008, Vol 582, Issue 10, p1537
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.03.050