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- Title
Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro
- Authors
Park, Chang-Hwan; Kang, Jin Sun; Yoon, Eun-Hye; Shim, Jae-Won; Suh-Kim, Haeyoung; Lee, Sang-Hun
- Abstract
Abstract: Roles of Nurr1 and neurogenin 2 (Ngn2) have been shown in midbrain dopamine (DA) neuron development. We present here rat and mouse species-dependent differences of Nurr1 and Ngn2 actions in DA neuron differentiation. Nurr1 exogene expression caused an efficient generation of tyrosine hydroxylase (TH)-positive DA cells from rat neural precursor cells (NPCs). Nurr1-induced TH+ cell yields were low and highly variable depending on the origins of NPCs in mouse cultures. Coexpression of Ngn2 repressed Nurr1-induced generation of TH+ cells in rat cultures. In clear contrast, a robust enhancement in Nurr1-induced DA cell yields was observed in mouse NPCs by Ngn2. These findings imply that DA neurons may develop differently in the midbrains of these two species.
- Subjects
NUCLEAR receptors (Biochemistry); DOPAMINE; TYROSINE; MICE
- Publication
FEBS Letters, 2008, Vol 582, Issue 5, p537
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2008.01.018