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- Title
Specific conformational epitope features of pathogenesis-related proteins mediating cross-reactivity between pollen and food allergens.
- Authors
Jimenez-Lopez, Jose; Gachomo, Emma; Ariyo, Oluwole; Baba-Moussa, Lamine; Kotchoni, Simeon
- Abstract
Selected members of plant pathogenesis-related and seed storage proteins represent specific groups of proteins with potential characteristics of allergens. Efforts to understand the mechanism by which pathogenesis-related proteins mediate a broad cross-reactivity in pollen-plant food allergens are still limited. In this study, computational biology approach was used to reveal specific structural implications and conservation of different epitopes from members of Bet v 1 and nsLTP protein families mediating cross-reactivity between pollen and food (fruits, vegetables, legumes, and nut/seeds) allergens. A commonly shared epitope conservation was found among all pollen and food Bet v 1 and nsLTP protein families, respectively. However, other allergenic epitopes were also specifically detected in each family. The implication of these conserved epitopes in a broad cross-reactivity for allergy clinical trials is here discussed.
- Subjects
PHYTOPATHOGENIC microorganisms; PLANT diseases; POLLEN; ALLERGENS; PROTEINS; LATEX; EPITOPES
- Publication
Molecular Biology Reports, 2012, Vol 39, Issue 1, p123
- ISSN
0301-4851
- Publication type
Article
- DOI
10.1007/s11033-011-0717-2