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- Title
DCE-MRI analysis methods for predicting the response of breast cancer to neoadjuvant chemotherapy: Pilot study findings.
- Authors
Li, Xia; Arlinghaus, Lori R.; Ayers, Gregory D.; Chakravarthy, A. Bapsi; Abramson, Richard G.; Abramson, Vandana G.; Atuegwu, Nkiruka; Farley, Jaime; Mayer, Ingrid A.; Kelley, Mark C.; Meszoely, Ingrid M.; Means‐Powell, Julie; Grau, Ana M.; Sanders, Melinda; Bhave, Sandeep R.; Yankeelov, Thomas E.
- Abstract
Purpose The purpose of this pilot study is to determine (1) if early changes in both semiquantitative and quantitative DCE-MRI parameters, observed after the first cycle of neoadjuvant chemotherapy in breast cancer patients, show significant difference between responders and nonresponders and (2) if these parameters can be used as a prognostic indicator of the eventual response. Methods Twenty-eight patients were examined using DCE-MRI pre-, post-one cycle, and just prior to surgery. The semiquantitative parameters included longest dimension, tumor volume, initial area under the curve, and signal enhancement ratio related parameters, while quantitative parameters included Ktrans, v e, kep, v p, and τ i estimated using the standard Tofts-Kety, extended Tofts-Kety, and fast exchange regime models. Results Our preliminary results indicated that the signal enhancement ratio washout volume and kep were significantly different between pathologic complete responders from nonresponders ( P < 0.05) after a single cycle of chemotherapy. Receiver operator characteristic analysis showed that the AUC of the signal enhancement ratio washout volume was 0.75, and the AUCs of kep estimated by three models were 0.78, 0.76, and 0.73, respectively. Conclusion In summary, the signal enhancement ratio washout volume and kep appear to predict breast cancer response after one cycle of neoadjuvant chemotherapy. This observation should be confirmed with additional prospective studies. Magn Reson Med 71:1592-1602, 2014. © 2013 Wiley Periodicals, Inc.
- Publication
Magnetic Resonance in Medicine, 2014, Vol 71, Issue 4, p1592
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.24782