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- Title
Imaging periodic currents using alternating balanced steady-state free precession.
- Authors
Buračas, Giedrius T.; Liu, Thomas T.; Buxton, Richard B.; Frank, Lawrence R.; Wong, Eric C.
- Abstract
Existing functional brain MR imaging methods detect neuronal activity only indirectly via a surrogate signal such as deoxyhemoglobin concentration in the vascular bed of cerebral parenchyma. It has been recently proposed that neuronal currents may be measurable directly using MRI (ncMRI). However, limited success has been reported in neuronal current detection studies that used standard gradient or spin echo pulse sequences. The balanced steady-state free precession (bSSFP) pulse sequence is unique in that it can afford the highest known SNR efficiency and is exquisitely sensitive to perturbations in free precession phase. It is reported herein that when a spin phase-perturbing periodic current is locked to an RF pulse train, phase perturbations are accumulated across multiple RF excitations and the spin magnetization reaches an alternating balanced steady state (ABSS) that effectively amplifies the phase perturbations due to the current. The alternation of the ABSS signal therefore is highly sensitive to weak periodic currents. Current phantom experiments employing ABSS imaging resulted in detection of magnetic field variations as small as 0.15nT in scans lasting for 36 sec, which is more sensitive than using gradient-recalled echo imaging. Magn Reson Med, 2007. © 2007 Wiley-Liss, Inc.
- Publication
Magnetic Resonance in Medicine, 2008, Vol 59, Issue 1, p140
- ISSN
0740-3194
- Publication type
Article
- DOI
10.1002/mrm.21457