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- Title
Genetic Alterations in Hungarian Patients with Papillary Thyroid Cancer.
- Authors
Tobiás, Bálint; Halászlaki, Csaba; Balla, Bernadett; Kósa, János; Árvai, Kristóf; Horváth, Péter; Takács, István; Nagy, Zsolt; Horváth, Evelin; Horányi, János; Járay, Balázs; Székely, Eszter; Székely, Tamás; Győri, Gabriella; Putz, Zsuzsanna; Dank, Magdolna; Valkusz, Zsuzsanna; Vasas, Béla; Iványi, Béla; Lakatos, Péter
- Abstract
The incidence of thyroid cancers is increasing worldwide. Some somatic oncogene mutations ( BRAF, NRAS, HRAS, KRAS) as well as gene translocations ( RET/ PTC, PAX8/ PPAR-gamma) have been associated with the development of thyroid cancer. In our study, we analyzed these genetic alterations in 394 thyroid tissue samples (197 papillary carcinomas and 197 healthy). The somatic mutations and translocations were detected by Light Cycler melting method and Real-Time Polymerase Chain Reaction techniques, respectively. In tumorous samples, 86 BRAF (44.2 %), 5 NRAS (3.1 %), 2 HRAS (1.0 %) and 1 KRAS (0.5 %) mutations were found, as well as 9 RET/ PTC1 (4.6 %) and 1 RET/ PTC3 (0.5 %) translocations. No genetic alteration was seen in the non tumorous control thyroid tissues. No correlation was detected between the genetic variants and the pathological subtypes of papillary cancer as well as the severity of the disease. Our results are only partly concordant with the data found in the literature.
- Subjects
INPATIENT care; HOSPITAL care; PATIENT satisfaction; DEMENTIA care mapping; PATIENT participation
- Publication
Pathology & Oncology Research, 2016, Vol 22, Issue 1, p27
- ISSN
1219-4956
- Publication type
Article
- DOI
10.1007/s12253-015-9969-9