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- Title
L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed Caenorhabditis elegans.
- Authors
Chen, Liangwen; Chen, Guijie; Gai, Tingting; Zhou, Xiuhong; Zhu, Jinchi; Wang, Ruiyi; Wang, Xuemei; Guo, Yujie; Wang, Yun; Xie, Zhongwen
- Abstract
L-theanine, a unique non-protein amino acid, is an important bioactive component of green tea. Previous studies have shown that L-theanine has many potent health benefits, such as anti-anxiety effects, regulation of the immune response, relaxing neural tension, and reducing oxidative damage. However, little is known concerning whether L-theanine can improve the clearance of mitochondrial DNA (mtDNA) damage in organisms. Here, we reported that L-theanine treatment increased ATP production and improved mitochondrial morphology to extend the lifespan of UVC-exposed nematodes. Mechanistic investigations showed that L-theanine treatment enhanced the removal of mtDNA damage and extended lifespan by activating autophagy, mitophagy, mitochondrial dynamics, and mitochondrial unfolded protein response (UPRmt) in UVC-exposed nematodes. In addition, L-theanine treatment also upregulated the expression of genes related to mitochondrial energy metabolism in UVC-exposed nematodes. Our study provides a theoretical basis for the possibility that tea drinking may prevent mitochondrial-related diseases.
- Subjects
CAENORHABDITIS; CAENORHABDITIS elegans; EPIGALLOCATECHIN gallate; UNFOLDED protein response; MITOCHONDRIAL DNA; MITOCHONDRIAL dynamics; IMMUNOREGULATION; GREEN tea
- Publication
Molecules, 2024, Vol 29, Issue 11, p2691
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29112691