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- Title
High Frequency of Tc22 and Th22 Cells in Myasthenia Gravis Patients and Their Significant Reduction after Thymectomy.
- Authors
Robat-Jazi, Behrouz; Hosseini, Mina; Shaygannejad, Vahid; Nafissi, Shahriar; Rezaei, Abbas; Mansourain, Marjan; Mirmosayyeb, Omid; Esmaeil, Nafiseh
- Abstract
Objectives: Myasthenia gravis (MG) is an autoimmune disease accompanied by a thymic pathology and in most patients thymectomy (TE) is used as the therapeutic approach. Both B and T cells play an important role in MG pathogenesis. Methods: Twelve pre- and post-TE MG patients and 12 healthy controls (HCs) were enrolled. The mean percentages of Th22 and Tc22 cells were evaluated in MG patients (before and 6 months after TE) and HCs. Results: The mean percentage of Tc22 cells in pre-TE patients was significantly higher than in HCs (p < 0.05), and after TE Tc22 cells significantly decreased compared to pre-TE (p < 0.05). The frequency of Th22 cells in pre-TE MG patients was not significantly different from HCs, but after TE Th22 cells were significantly decreased compared to pre-TE (p < 0.05). Conclusion: Our findings suggest a possible role of Th22 and Tc22 in MG pathogenesis.
- Publication
Neuroimmunomodulation, 2018, Vol 25, Issue 2, p80
- ISSN
1021-7401
- Publication type
Article
- DOI
10.1159/000490855