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- Title
Protective effect of methylsulfonylmethane in caerulein‐induced acute pancreatitis and associated lung injury in mice.
- Authors
Velusamy, Ranjith Kumar; Tamizhselvi, Ramasamy
- Abstract
Abstract: Objectives: In the present study, we have elaborated the anti‐inflammatory mechanism of MSM through homing of CD34+ stem cells towards an inflamed region by regulating hydrogen sulfide (H2S) in an in vivo model of caerulein‐induced acute pancreatitis (AP) and associated lung injury. Methods: Male Swiss mice were treated with hourly intraperitoneal injections of caerulein (50 μg/kg) for 6 h. MSM (500 mg/kg) was administered intraperitoneally 1 h after the first caerulein injection (therapeutic). The serum amylase activity and myeloperoxidase (MPO) activity in lung and pancreas were measured. The levels of H2S and interleukin (IL)‐1β, cystathionine‐γ‐lyase (CSE) and CD34+ expressions in pancreas and lungs were determined by RT‐PCR and ELISA. Key Findings: Methylsulfonylmethane significantly ameliorated pancreas and lung histopathological changes, decreased serum amylase, MPO activity and inhibited caerulein‐induced IL‐1β expression. Furthermore, MSM reduced caerulein‐induced H2S levels by alleviating the expression of CSE in pancreas and lungs and increased CD34 expression and inhibited nuclear factor (NF)‐κB translocation in caerulein‐induced AP and associated lung injury. Conclusions: These findings indicate that MSM can effectively reduce inflammatory responses and induce the homing of CD34+ cells to the injured tissues.
- Subjects
DIMETHYL sulfone; CERULETIDE; PANCREATITIS; LUNG injuries; ANTI-inflammatory agents; HYDROGEN sulfide
- Publication
Journal of Pharmacy & Pharmacology, 2018, Vol 70, Issue 9, p1188
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1111/jphp.12946