We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Durability of bioprosthetic aortic valve replacement in patients under the age of 60 years — 1-year follow-up from the prospective INDURE registry.
- Authors
Meuris, Bart; Roussel, Jean-Christian; Borger, Michael A; Siepe, Matthias; Stefano, Pierluigi; Laufer, Günther; Langanay, Thierry; Theron, Alexis; Grabenwöger, Martin; Binder, Konrad; Demers, Philippe; Pessotto, Renzo; Leeuwen, Wouter van; Bourguignon, Thierry; Canovas, Sergio; Mariscalco, Giovanni; Coscioni, Enrico; Dagenais, Francois; Wendler, Olaf; Polvani, Gianluca
- Abstract
Open in new tab Download slide OBJECTIVES We report 1-year safety and clinical outcomes in patients <60 years undergoing bioprosthetic surgical aortic valve intervention. METHODS The INSPIRIS RESILIA Durability Registry is a prospective, multicentre registry to assess clinical outcomes of patients <60 years. Patients with planned SAVR with or without concomitant replacement of the ascending aorta and/or coronary bypass surgery were included. Time-related valve safety, haemodynamic performance and quality of life (QoL) at 1 year were assessed. RESULTS A total of 421 patients were documented with a mean age of 53.5 years, 76.5% being male and 27.2% in NYHA class III/IV. Outcomes within 30 days included cardiovascular-related mortality (0.7%), time-related valve safety (VARC-2; 5.8%), thromboembolic events (1.7%), valve-related life-threatening bleeding (VARC-2; 4.3%) and permanent pacemaker implantation (3.8%). QoL was significantly increased at 6 months and sustained at 1 year. Freedom from all-cause mortality at 1 year was 98.3% (95% confidence interval 97.1; 99.6) and 81.8% were NYHA I versus 21.9% at baseline. No patient developed structural valve deterioration stage 3 (VARC-3). The mean aortic pressure gradient was 12.6 mmHg at 1 year and the effective orifice area was 1.9 cm2. CONCLUSIONS The 1-year data from the INSPIRIS RESILIA valve demonstrate good safety and excellent haemodynamic performance as well as an early QoL improvement. Clinical trial registration clinicaltrials.gov: NCT03666741.
- Publication
Interdisciplinary Cardiovascular & Thoracic Surgery, 2023, Vol 37, Issue 4, p1
- ISSN
2753-670X
- Publication type
Article
- DOI
10.1093/icvts/ivad115