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- Title
Quetiapine Significantly Improves the Effectiveness of Radiotherapy in Combating Hepatocellular Carcinoma Progression in a Hep3B Xenograft Mouse Model.
- Authors
JR-DI YANG; YU-CHANG LIU; HSIAO-CHIA WANG; FEI-TING HSU; TSAI LAN LIAO; MENG-CHU HUANG; JIANN-HWA CHEN
- Abstract
Background/Aim: In hepatocellular carcinoma (HCC) treatment, radiotherapy (RT) stands as a pivotal approach, yet the emergence of radioresistance poses a formidable challenge. This study aimed to explore the potential synergy between quetiapine and RT for HCC treatment. Materials and Methods: A Hep3B xenograft mouse model was used, the investigation tracked tumor progression, safety parameters, and molecular mechanisms. Results: The findings revealed a synergistic anti-HCC effect when quetiapine was coupled with RT that prolonged tumor growth time and a significantly higher growth inhibition rate compared to the control group. Safety assessments indicated minimal pathological changes, suggesting potential of quetiapine in mitigating RT-induced alterations in liver and kidney functions. Mechanistically, the combination suppressed metastasis and angiogenesis-related proteins, while triggering the activation of apoptosis-related proteins via targeting Epidermal growth factor receptor (EGFR)-mediated signaling. Conclusion: The potential of the quetiapine and RT combination is emphasized, offering enhanced anti-HCC efficacy, a safety profile, and positioning quetiapine as a radiosensitizer for HCC treatment.
- Subjects
QUETIAPINE; HEPATOCELLULAR carcinoma; CANCER radiotherapy; DISEASE progression; XENOGRAFTS
- Publication
In Vivo, 2024, Vol 38, Issue 3, p1079
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.13542