We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Relationship Between Radiation Pneumonitis Following Definitive Radiotherapy for Non-small Cell Lung Cancer and Isodose Line.
- Authors
SHIGENOBU WATANABE; ICHIRO OGINO; DAISUKE SHIGENAGA; MASAHARU HATA
- Abstract
Background/Aim: It is important to identify radiation pneumonitis above Common Terminology Criteria for Adverse Events Grade 2 (G2) in order to safely continue durvalumab maintenance after chemoradiotherapy for advanced lung cancer. The aim of this study was to discover factors that predict pneumonitis above G2. Patients and Methods: A follow-up computed tomography (CT) image was superimposed on the planning CT image using deformable image registration (DIR). The pneumonitis area was contoured on follow-up CT after DIR and the dose-volume histogram parameters of the contoured pneumonitis area were calculated. Results: V5 (Percentage of total volume receiving ≥5 Gy) to V50 of pneumonitis were significantly lower in patients with G2 pneumonitis than in those with G1 pneumonitis. The pneumonitis V15 was the most significant. The group with pneumonitis V15 <87.10% had significantly more G2 pneumonitis than the group with pneumonitis V15 ≥87.10%. Conclusion: Pneumonitis V15 <87.10% was a risk factor for G2 pneumonitis.
- Subjects
PNEUMONIA; NON-small-cell lung carcinoma; CANCER radiotherapy; CHEMORADIOTHERAPY; MEDICATION safety
- Publication
In Vivo, 2021, Vol 35, Issue 6, p3441
- ISSN
0258-851X
- Publication type
Article
- DOI
10.21873/invivo.12644