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- Title
THE EFFECT OF STREPTOCOCCUS ON THE NASAL AND OROPHARYNGEAL MUCOSA TO THE CYTOKINE RESPONSE OF CHILDREN WITH INFECTIOUS MONONUCLEOSIS.
- Authors
Guz, O.; Kuznetsov, S.
- Abstract
The article presents the results of a comparative reaction of interleukins of blood in children with infectious mononucleosis (IM) in different periods of the disease, with the presence and absence of dissemination of streptococcus on the nasal and oropharyngeal mucosa. To achieve the goal, 60 children aged from three to seven years with infectious mononucleosis, who were treated at the Regional Children’s Infectious Clinical Hospital of Kharkiv, Ukraine, were examined. Infectious mononucleosis was confirmed by positive results of disease markers by ELISA (anti-EBV IgM and IgG) and PCR (detection of EBV DNA in the blood). The immune status of patients was assessed by indicators of the levels of interleukins 1β, 4, TNFα. In 30 children (the first group), Streptococcus pyogenes was isolated in concentrations of 10-5 and higher during bacteriological examination of the nasal and oropharyngeal mucosa. The second group (30 children) – streptococcus was not detected on the nasal and oropharyngeal mucosa. Analysis of the study results found that the presence in patients of streptococcus on the nasal and oropharyngeal mucosa in the acute period of infectious mononucleosis leads to a more pronounced reaction of pro-inflammatory interleukins in their blood and inhibition of the response of anti-inflammatory interleukin 4 (P < 0.05). Later, there was a slow decrease in the levels of interleukin 1, TNF-α and inhibition of the increase in the content of IL-4. We believe that determining the levels of interleukins may allow us to predict the severity and course of the disease in the early stages of the disease. Сt can also serve as a promising direction for improving the treatment of patients and, therefore, reducing adverse outcomes.
- Subjects
MONONUCLEOSIS; BLOOD diseases; STREPTOCOCCUS; INTERLEUKINS; IMMUNITY
- Publication
General Medicine / Obsta Medicina, 2019, Vol 21, Issue 6, p3
- ISSN
1311-1817
- Publication type
Article