We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Proposal of Quick Diagnostic Criteria for Disseminated Intravascular Coagulation.
- Authors
Wada, Hideo; Yamamoto, Akitaka; Tomida, Masaki; Ichikawa, Yuhuko; Ezaki, Minoru; Masuda, Jun; Yoshida, Masamichi; Fukui, Shunsuke; Moritani, Isao; Inoue, Hidekazu; Shiraki, Katsuya; Suzuki, Kei; Imai, Hiroshi; Shimaoka, Motomu; Shimpo, Hideto
- Abstract
Background. The diagnostic criteria for disseminated intravascular coagulation (DIC) vary and are complicated and the cut-off values are different. Simple and quick diagnostic criteria for DIC are required in physicians for critical care. Material and methods. Platelet counts, prothrombin time–international normalized ratio (PT-INR) and D-dimer levels were examined in 1293 critical ill patients. Adequate cut-off values of these parameters were determined and a quick DIC score using these biomarkers was proposed. The quick DIC score was evaluated using a receiver operating characteristic (ROC) analysis. Results. Using the Japanese Ministry of Health, Labor and Welfare diagnostic criteria, 70 and 109 patients were diagnosed with DIC and pre-DIC, respectively. The ROC analysis of factors difference between DIC and non-DIC, revealed the following cut-off values: PT-INR, 1.20; platelet count, 12.0 × 1010/L and D-dimer, 10.0 μg/mL. Based on the above results, the quick DIC score system was proposed. All patients with DIC had a quick DIC score of 3, 4 or 5, and 85.3% of the patients with pre-DIC had a quick DIC score of ≥3 points. All patients with pre-DIC had a score of ≥2 points. In the ROC analysis, the area under the curve was 0.997 for DIC vs. non-DIC, and 0.984 for pre-DIC + DIC vs. non-DIC, and the cut-off value was 3 points for DIC and 2 points for DIC + pre-DIC. The quick DIC scores of non-survivors were significantly higher than those of survivors. Conclusions. The Quick DIC score system is a simple and useful tool that can be used for the diagnosis of DIC and pre-DIC. Further evaluation of the quick DIC score system in a large-scale study is required.
- Subjects
DISSEMINATED intravascular coagulation; RECEIVER operating characteristic curves; PLATELET count; FACTOR analysis; FIBRIN fragment D
- Publication
Journal of Clinical Medicine, 2022, Vol 11, Issue 4, pN.PAG
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm11041028