We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Should We Stop Collecting the Preoperative Autologous Blood before Bone Marrow Harvest?
- Authors
Lysák, Daniel; Hejretová, Lenka; Hrabětová, Marcela; Jindra, Pavel; Tomuleasa, Ciprian; Tanase, Alina; Colita, Anca
- Abstract
Preoperative autologous blood donation (PAD) in bone marrow (BM) donors is performed to meet potential post-harvest transfusion needs and to avoid the risk of allogeneic transfusions. We reviewed retrospectively bone marrow harvests in 216 healthy donors during a ten-year period to determine the use of autologous blood. All donors except four had undergone PAD. The initial hemoglobin level of 153 g/L (male donors) and 135 g/L (female donors), respectively, decreased by about 8 g/L after preoperative blood donation and by 23 g/L after bone marrow harvest (medians). Autologous blood was administered to 70% of donors, 30% of the units remained unused. The evaluation of the risk of reaching transfusion threshold (<115 g/L males, <105 g/L females) revealed that donors with initial hemoglobin above 145 g/L and those weighing above 75 kg have minimal risk of requiring blood substitution (about 10%). A larger volume of bone marrow was obtained from male compared to female donors (1300 vs. 1100 mL) because of their higher body weight, which resulted in a higher number of procured nucleated cells (362 vs. 307 × 106/kg TNC, ns). The donor-recipient weight difference predicted the probability of sufficient collection. Only 1.5% of donors weighing ≥ 20 kg more than recipients failed to reach ≥3 × 108/kg TNC recipient. Our findings affirm previous data that PAD is unnecessary for healthy marrow donors and may be indicated individually after considering the pre-collection hemoglobin level, donor and recipient weight, and expected blood loss. Reasonable substitution cut-offs have to be set together with clinical symptom evaluation. The effective use of PAD also requires an adequate time interval between PAD and BM harvest.
- Subjects
BONE marrow; POSTHARVEST diseases; BODY weight; RISK assessment; HEMOGLOBINS
- Publication
Journal of Clinical Medicine, 2021, Vol 10, Issue 10, p2134
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm10102134