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- Title
Could Periodontal Disease through Periopathogen Fusobacterium nucleatum Be an Aggravating Factor for Gastric Cancer?
- Authors
Șurlin, Petra; Nicolae, Flavia Mirela; Șurlin, Valeriu Marin; Pătrașcu, Ștefan; Ungureanu, Bogdan Silviu; Didilescu, Andreea Cristiana; Gheonea, Dan Ionuț
- Abstract
Periodontal disease affects the supporting tissues of the teeth, being a chronic inflammatory disease caused by specific microorganisms from subgingival biofilm. Fusobacterium nucleatum is a Gram-negative anaerobic bacterium that acts as a periodontal pathogen, being an important factor in linking Gram-positive and Gram-negative bacteria in the periodontal biofilm, but its involvement in systemic diseases has also been found. Several studies regarding the implication of Fusobacterium nucleatum in gastro-enterological cancers have been conducted. The present review aims to update and systematize the latest information about Fusobacterium nucleatum in order to evaluate the possibility of an association between periodontal disease and the evolution of gastroenterological cancers through the action of Fusobacterium nucleatum, highlighting gastric cancer. This would motivate future research on the negative influence of periodontal pathology on the evolution of gastric cancer in patients suffering from both pathologies.
- Subjects
PORPHYROMONAS gingivalis; STOMACH cancer; PERIODONTAL disease; FUSOBACTERIUM; GRAM-negative anaerobic bacteria; GRAM-positive bacteria
- Publication
Journal of Clinical Medicine, 2020, Vol 9, Issue 12, p3885
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm9123885