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- Title
Preparation and properties of gelatin-chitosan/nano-SiO<sub>2</sub> composite for in-situ drug loading.
- Authors
ZHAO Wenboe; YANG Fan; LI Qiuning; HOU Xueyan; ZHANG Yuqi; WANG Jijiang
- Abstract
The gelatin-chitosan/nano-SiO2 composite films were prepared by gelatin, chitosan and nano-SiO2. The swelling and mechanical strength of the composite films were tested. Then the gelatin-chitosan/nano-SiO2 composite films were used in the in-situ loading of aspirin to study the effect of nano-SiO2 dosage and aspirin dosage on the sustained-release properties of the composite membrane. The results showed that the introduction of nano-SiO2 can reduce the swelling of the composite films in water and improve the mechanical strength of the composite films. With the increase of the amount of nano-SiO2 the sustained-release properties of the composite membrane in situ loading of aspirin was increased. When the dosage of aspirin was 0.5%, gelatin-chitosan/ nano-SiO2, composite films in-situ drug loaded had good sustained-release performance.
- Publication
Journal of Functional Materials / Gongneng Cailiao, 2018, Vol 49, Issue 5, p05126
- ISSN
1001-9731
- Publication type
Article
- DOI
10.3969/j.issn.1001-9731.2018.05.022