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- Title
Higher rates of carbapenem‐related seizures in older hospitalised adults.
- Authors
Neo, Han‐Yee; Tan, Keng‐Teng; Caroline, Caroline; Wei‐Han Ng, David; Pei‐Ying Ho, Esther; Lim, Jun‐Pei; Hsien‐Xiong Lee, Raphael; Choon‐Kiat Tan, Nigel; Chien‐Boon Lye, David; Ding, Yew‐Yoong
- Abstract
Clinical experience suggests higher occurrence of carbapenem‐associated seizures in the elderly than what is reported in the available literature (range between 0.2% and 0.7%). An audit of 1345 patients with age 60 years or older, who received imipenem, ertapenem or meropenem during their acute hospitalisation found 32 (2.4%) subjects developed seizures. Subjects with more than one central nervous system disorders were 11.6 times more likely to develop seizures (odds ratio 11.61, P < 0.001) and subjects with prior history of seizures is associated with four times greater risks (odds ratio 4.02, P = 0.005). Physicians should exercise caution when prescribing carbapenems in elderly, especially those with known epilepsy and a high number of intracranial pathologies.
- Subjects
CONVULSIONS -- Risk factors; RISK factors of spasms; CENTRAL nervous system diseases; RISK assessment; CARBAPENEMS; ODDS ratio; IMIPENEM; MEROPENEM; DISEASE risk factors
- Publication
Internal Medicine Journal, 2020, Vol 50, Issue 1, p123
- ISSN
1444-0903
- Publication type
Article
- DOI
10.1111/imj.14693