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- Title
An open‐label prospective study to assess short incubation time white LED light photodynamic therapy in the treatment of superficial basal cell carcinoma.
- Authors
Hellen, Rebecca; Dhonncha, Eilis Nic; Havelin, Alison; Kavanagh, Ann; Moriarty, Blaithin; Collins, Paul
- Abstract
Artificial white LED light photodynamic therapy (awl‐PDT) is an effective, pain‐free treatment for actinic keratosis. The efficacy of awl‐PDT in the treatment of superficial basal cell carcinoma (sBCC) has not been assessed. Patients with histologically confirmed sBCC underwent two treatments of awl‐PDT 1 week apart. Lesions were incubated with methyl 5‐aminolaevulinic acid for 30 min and then illuminated using the Maquet Power LED 500 theatre light (405‐800nm, 140 000 lux) to deliver an equivalent red light dose of 75 J/cm2 at a rate of 55 mW/cm2. Pain was measured using a visual analogue scale during treatment. Clinical response was assessed at day 28. Follow‐up continued 3 months for 1 year. Cosmetic outcome was assessed at 3 months and 1 year. Twenty‐eight patients with 36 lesions and a mean age of 63.64 (SD 2.62) were recruited. The median lesion size was 15 mm (IQR 8.75). The response rate at day 28 was 100%. Recurrence rates were 3/36 (8.3%) at 3 months, 6/36 (16.7%) at 6 months, 10/36 (27.8%) at 9 months and 11/36 (30.6%) at 1 year. Median pain scores were 0/100 (IQR 0) and 0/100 (IQR 5) during treatments one and two, respectively. Cosmetic outcome was excellent or good in the majority of cases. Although initially effective for sBCC at 28 days, 30.6% of lesions recurred 1 year after awl‐PDT. Pain scores were negligible, and the cosmetic outcome was favourable. Further head‐to‐head studies with optimised protocols are required to determine if awl‐PDT has a role in the treatment of sBCC.
- Subjects
BASAL cell carcinoma; PHOTOTHERAPY; PHOTODYNAMIC therapy; ACTINIC keratosis; LONGITUDINAL method
- Publication
Photodermatology, Photoimmunology & Photomedicine, 2022, Vol 38, Issue 4, p322
- ISSN
0905-4383
- Publication type
Article
- DOI
10.1111/phpp.12750