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- Title
Polypodium leucotomos inhibits ultraviolet B radiation-induced immunosuppression.
- Authors
Siscovick, Jonathan R.; Zapolanski, Tamar; Magro, Cynthia; Carrington, Kristel; Prograis, Shannon; Nussbaum, Marnie; Gonzalez, Salvador; Ding, Wanhong; Granstein, Richard D.
- Abstract
Background: An extract of the tropical fern Polypodium leucotomos (PL) administered orally to mice inhibits ultraviolet B (UVB) radiation-induced skin cancer formation. UVB-induced murine skin cancers occur, in part, because of UVB-induced immunosuppression. Thus, we examined whether PL inhibits UVB-suppression of the induction of contact hypersensitivity (CHS) locally or systemically. Methods: C57BL/6 mice received standard drinking water or water-containing PL. In the local model, mice were shaved on the dorsum and exposed to 3500 J/m2 of UVB radiation daily for 4 days. Control mice were not irradiated. After the last irradiation they were sensitized to oxazolone topically at the irradiated site. To examine the ability of PL to inhibit systemic UVB-induced immunosuppression, mice were given 10 000 J/m2 of UVB radiation once and immunized at a non-exposed site 3 days later. Six days after immunization (in both models), mice were challenged on the ears with oxazolone and 24/48 h ear swelling assessed. Results: PL in drinking water significantly reduced the inhibition of CHS observed with exposure to UVB radiation in both the local and systemic models. Conclusions: The ability of PL to inhibit UVB radiation-induced immune suppression may explain, in part, its ability to inhibit UVR-induced skin cancer induction in mice.
- Subjects
POLYPODIUM; SKIN cancer; ULTRAVIOLET radiation; IMMUNOSUPPRESSION; CONTACT dermatitis; IRRADIATION
- Publication
Photodermatology, Photoimmunology & Photomedicine, 2008, Vol 24, Issue 3, p134
- ISSN
0905-4383
- Publication type
Article
- DOI
10.1111/j.1600-0781.2008.00352.x