We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Recent Advances and Future Perspectives in Polymer-Based Nanovaccines.
- Authors
Pippa, Natassa; Gazouli, Maria; Pispas, Stergios
- Abstract
Vaccination is the most valuable and cost-effective health measure to prevent and control the spread of infectious diseases. A significant number of infectious diseases and chronic disorders are still not preventable by existing vaccination schemes; therefore, new-generation vaccines are needed. Novel technologies such as nanoparticulate systems and adjuvants can enable safe and effective vaccines for difficult target populations such as newborns, elderly, and the immune-compromised. More recently, polymer-based particles have found application as vaccine platforms and vaccine adjuvants due to their ability to prevent antigen degradation and clearance, coupled with enhanced uptake by professional antigen-presenting cells (APCs). Polymeric nanoparticles have been applied in vaccine delivery, showing significant adjuvant effects as they can easily be taken up by APCs. In other words, polymer-based systems offer a lot of advantages, including versatility and flexibility in the design process, the ability to incorporate a range of immunomodulators/antigens, mimicking infection in different ways, and acting as a depot, thereby persisting long enough to generate adaptive immune responses. The aim of this review is to summarize the properties, the characteristics, the added value, and the limitations of the polymer-based nanovaccines, as well as the process of their development by the pharmaceutical industry.
- Subjects
VACCINE effectiveness; INFECTIOUS disease transmission; COMMUNICABLE diseases; NEWBORN infants; CHRONIC diseases
- Publication
Vaccines, 2021, Vol 9, Issue 6, p558
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines9060558