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- Title
The first competing risk survival nomogram in patients with papillary renal cell carcinoma.
- Authors
Su, Xing; Hou, Niu-Niu; Yang, Li-Jun; Li, Peng-Xiao; Yang, Xiao-Jian; Hou, Guang-Dong; Gao, Xue-Lin; Ma, Shuai-Jun; Guo, Fan; Zhang, Rui; Zhang, Wu-He; Qin, Wei-Jun; Wang, Fu-Li
- Abstract
There is still a lack of competing risk analysis of patients with papillary renal cell carcinoma (pRCC) following surgery. We performed the cumulative incidence function (CIF) to estimate the absolute risks of cancer-specific mortality (CSM) and other-cause mortality (OCM) of pRCC over time, and constructed a nomogram predicting the probability of 2-, 3- and 5-year CSM based on competing risk regression. A total of 5993 pRCC patients who underwent nephrectomy between 2010 and 2016 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. The 2-, 3-, 5-year CSM rates were 3.2%, 4.4% and 6.5%, respectively, and that of OCM were 3.2%, 5.0% and 9.3%, respectively. The estimates of 5-year cumulative mortality were most pronounced among patients aged > 75 years in OCM (17.0%). On multivariable analyses, age, tumor grade, T stage, N stage, and with or without bone, liver and lung metastases were identified as independent predictors of CSM following surgery and were integrated to generate the nomogram. The nomogram achieved a satisfactory discrimination with the AUCt of 0.730 at 5-year, and the calibration curves presented impressive agreements. Taken together, age-related OCM is a significant portion of all-cause mortality in elderly patients and our nomogram can be used for decision-making and patient counselling.
- Subjects
RENAL cell carcinoma; KIDNEY surgery; NOMOGRAMS in electronics; CANCER-related mortality; NEPHRECTOMY; OLDER patients
- Publication
Scientific Reports, 2021, Vol 11, Issue 1, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/s41598-021-91217-z