We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of Low Arousal Threshold Obstructive Sleep Apnea Manifestations with Body Fat and Water Distribution.
- Authors
Hsu, Wen-Hua; Yang, Cheng-Chang; Tsai, Cheng-Yu; Majumdar, Arnab; Lee, Kang-Yun; Feng, Po-Hao; Tseng, Chien-Hua; Chen, Kuan-Yuan; Kang, Jiunn-Horng; Lee, Hsin-Chien; Wu, Cheng-Jung; Kuan, Yi-Chun; Liu, Wen-Te
- Abstract
Obstructive sleep apnea (OSA) with a low arousal threshold (low-ArTH) phenotype can cause minor respiratory events that exacerbate sleep fragmentation. Although anthropometric features may affect the risk of low-ArTH OSA, the associations and underlying mechanisms require further investigation. This study investigated the relationships of body fat and water distribution with polysomnography parameters by using data from a sleep center database. The derived data were classified as those for low-ArTH in accordance with criteria that considered oximetry and the frequency and type fraction of respiratory events and analyzed using mean comparison and regression approaches. The low-ArTH group members (n = 1850) were significantly older and had a higher visceral fat level, body fat percentage, trunk-to-limb fat ratio, and extracellular-to-intracellular (E–I) water ratio compared with the non-OSA group members (n = 368). Significant associations of body fat percentage (odds ratio [OR]: 1.58, 95% confident interval [CI]: 1.08 to 2.3, p < 0.05), trunk-to-limb fat ratio (OR: 1.22, 95% CI: 1.04 to 1.43, p < 0.05), and E–I water ratio (OR: 1.32, 95% CI: 1.08 to 1.62, p < 0.01) with the risk of low-ArTH OSA were noted after adjustments for sex, age, and body mass index. These observations suggest that increased truncal adiposity and extracellular water are associated with a higher risk of low-ArTH OSA.
- Subjects
SLEEP apnea syndromes; WATER distribution; FAT; BODIES of water; BODY mass index; ODDS ratio
- Publication
Life (2075-1729), 2023, Vol 13, Issue 5, p1218
- ISSN
2075-1729
- Publication type
Article
- DOI
10.3390/life13051218