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- Title
Glycine Effect on the Expression Profile of Orphan Receptors GPR21, GPR26, GPR39, GPR82 and GPR6 in a Model of Inflammation in 3T3-L1 Cells.
- Authors
Gutiérrez-Rojas, Rocío Alejandra; Aguayo-Cerón, Karla Aidee; Vargas-De-León, Cruz; Cabrera-Becerra, Sandra Edith; Almanza-Pérez, Julio Cesar; Huang, Fengyang; Villafaña, Santiago; Romero-Nava, Rodrigo
- Abstract
According to the International Union of Basic and Clinical Pharmacology (IUPHAR), glycine as a ligand has different natural/endogenous targets, e.g., the glycine receptor (consisting of glycine receptor 1, 2, 3, 4 and subunits), ionotropic glutamate receptors as a coagonist (GluN1, GluN2A, GluN2B, GluN2C and GluN2D), GPRC6 receptors and transporters, which move this compound across the lipid membrane (GlyT1 and GlyT2). Keywords: orphan receptors; glycine; inflammation; adipokines EN orphan receptors glycine inflammation adipokines 1687 13 11/17/22 20221101 NES 221101 1. (A) GPR21 gene expression; (B) GPR26 gene expression; (C) GPR39 gene expression; (D) GPR82 gene expression; and (E) GPR6 gene expression. Using PCA, we have shown that orphan receptor gene expression, and the pro- and anti-inflammatory effects of TNF- and glycine, can be described using a mathematical technique (PCA) to further enhance the field's knowledge and understanding of the role of orphan receptors in the inflammatory process.
- Subjects
G protein coupled receptors; GLYCINE receptors; GENE expression; GLYCINE agents; WEIGHT loss; GHRELIN receptors; ORPHANS
- Publication
Life (2075-1729), 2022, Vol 12, Issue 11, p1687
- ISSN
2075-1729
- Publication type
Article
- DOI
10.3390/life12111687