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- Title
High Skin Sympathetic Nerve Activity in Patients with Recurrent Syncope.
- Authors
Huang, Tien-Chi; Chi, Nai-Yu; Lan, Chih-Sung; Chen, Chang-Jen; Jhuo, Shih-Jie; Lin, Tsung-Han; Liu, Yi-Hsueh; Chou, Li-Fang; Chang, Chien-Wei; Liao, Wei-Sheng; Kao, Pei-Heng; Hsu, Po-Chao; Lee, Chee-Siong; Lin, Yi-Hsiung; Lee, Hsiang-Chun; Lu, Ye-Hsu; Yen, Hsueh-Wei; Lin, Tsung-Hsien; Su, Ho-Ming; Lai, Wen-Ter
- Abstract
(1) Background: The autonomic imbalance plays a role in vasovagal syncope (VVS) diagnosed by head-up tilting test (HUT). neuECG is a new method of recording skin electrical signals to simultaneously analyze skin sympathetic nerve activity (SKNA) and electrocardiogram. We hypothesize that SKNA is higher in subjects with tilt-positive than tilt-negative and the SKNA surges before syncope. (2) Methods: We recorded neuECG in 41 subjects who received HUT (according to the "Italian protocol"), including rest, tilt-up, provocation and recovery phases. Data were analyzed to determine the average SKNA (aSKNA, μV) per digitized sample. Electrocardiogram was used to calculate standard deviation of normal-to-normal beat intervals (SDNN). The "SKNA-SDNN index" was calculated by rest aSKNA multiplied by the ratio of tilt-up to rest SDNN. (3) Results: 16 of 41 (39%) subjects developed syncope. The aSKNA at rest phase is significantly higher in the tilt-positive (1.21 ± 0.27 µV) than tilt-negative subjects (1.02 ± 0.29 µV) (p = 0.034). There are significant surges and withdraw of aSKNA 30 s before and after syncope (both p ≤ 0.006). SKNA-SDNN index is able to predict syncope (p < 0.001). (4) Conclusion: Higher SKNA at rest phase is associated with positive HUT. The SKNA-SDNN index is a novel marker to predict syncope during HUT.
- Subjects
SYNCOPE; AUTONOMIC nervous system; NERVES; HEART beat
- Publication
Journal of Personalized Medicine, 2021, Vol 11, Issue 11, p1053
- ISSN
2075-4426
- Publication type
Article
- DOI
10.3390/jpm11111053