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- Title
Enzyme Inhibitory and Molecular Docking Studies on Some Organic Molecules of Natural Occurrence.
- Authors
Abbasi, Muhammad Athar; Hussain, Ghulam; Aziz-ur-Rehman; Shahwar, Durre; Khan, Khalid Mohammed; Mohyuddin, Ayesha; Ashraf, Muhammad; Rahman, Jameel; Lodhi, Muhammad Arif; Khan, Farman Ali
- Abstract
In the present study, in vitro enzyme inhibitory studies on cinchonidine (1), cinchonine (2), quinine (3), noscapine (narcotine, 4) and santonine (5) were carried out. The various enzymes included in the study were lipoxygenase, xanthine oxidase, acetyl cholinesterase, butyryl cholinesterase and protease. The results revealed that 2, 3, and 4 were moderate active against lipoxygenase and xanthine oxidase enzymes. The molecule 3 possessed weak activity against butyryl cholinesterase enzyme while remaining molecules were inactive against this enzyme. However, all these compounds were inactive against acetyl cholinestrase and protease enzymes. The synthesized compounds were computationally docked into the active site of lipoxygenase enzyme. The compounds 3 and 4 showed decent interactions, hence strengthening the observed results.
- Subjects
ENZYME inhibitors; XANTHINE oxidase; LIPOXYGENASES regulation; CINCHONIDINE; MOLECULAR physics; INTERMOLECULAR forces; REACTIVE oxygen species
- Publication
Journal of the Chemical Society of Pakistan, 2016, Vol 38, Issue 1, p166
- ISSN
0253-5106
- Publication type
Article