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- Title
An Update on the Role of Adipose Tissues in Psoriasis.
- Authors
Wong, Yisheng; Nakamizo, Satoshi; Tan, Kahbing J.; Kabashima, Kenji
- Abstract
Psoriasis is a common chronic inflammatory skin disease that is increasingly being recognized as a disease that not only affects the skin but also has multi-systemic implications. The pathophysiological link between psoriasis and obesity is becoming increasingly elucidated by recent studies. The cross-talk between adipocytes and the immune system via various mediators such as adipokines could explain how obesity contributes to psoriasis. The effects of obesity on adipocytes include upregulation of pro-inflammatory adipokines such as leptin and resistin, downregulation of anti-inflammatory adipokine, and also the stimulation of pro-inflammatory cytokine production by macrophages. This article provides an update on the role of adipose tissues in psoriasis.
- Subjects
ADIPOSE tissues; PSORIASIS; ADIPOKINES; FAT cells; OBESITY; PATHOLOGICAL physiology
- Publication
Frontiers in Immunology, 2019, pN.PAG
- ISSN
1664-3224
- Publication type
Article
- DOI
10.3389/fimmu.2019.01507