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- Title
Pharmacokinetic profiles of florfenicol in spotted halibut, Verasper variegatus, at two water temperatures.
- Authors
Chang, Zhiqiang; Chen, Zhao; Gao, Haiyu; Zhai, Qianqian; Li, Jian
- Abstract
The pharmacokinetic profiles of florfenicol in the spotted halibut (Verasper variegatus) were investigated at 15 and 20°C water temperatures, respectively. Florfenicol content in plasma samples was analyzed using an HPLC method. Drug concentration versus time data were best fitted to a three‐compartment model after a single intravenous administration (15 mg/kg BW), and fitted to a two‐compartment model after an oral administration (30 mg/kg BW) at 15 and 20°C. The florfenicol concentration in the blood increased slowly during the 12 hr following an oral administration at 15°C, with a peak concentration (Cmax) of 9.1 mg/L, and then declined gradually. The half‐lives of absorption, distribution, and elimination phase were 2.18, 5.66 and 14.25 hr, respectively. The bioavailability (F) was calculated to be 24.14%. After an oral administration at 20°C, shorter half‐lives of absorption (1.33 hr), distribution (2.51 hr) and elimination (9.71 hr), a higher Cmax (12.2 mg/L), and a similar F (23.98%) were found. Based on the pharmacokinetics and pharmacodynamics, an oral dose of 30 mg/kg BW was suggested to be efficacious for bacterial disease control in spotted halibut farming.
- Subjects
PHARMACOKINETICS; HALIBUT; WATER temperature; PEAK concentration (Atmospheric chemistry); ADSORPTION (Chemistry); BACTERIAL diseases
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2019, Vol 42, Issue 1, p121
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/jvp.12668