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- Title
Spotlight on Trans-Synaptic Degeneration in the Visual Pathway in Multiple Sclerosis.
- Authors
Filippatou, Angeliki G; Calabresi, Peter A; Saidha, Shiv; Murphy, Olwen C
- Abstract
A putative mechanism of neurodegeneration in multiple sclerosis (MS) is trans-synaptic degeneration (TSD), whereby injury to a neuron leads to degeneration of synaptically connected neurons. The visual system is commonly involved in MS and provides an ideal model to study TSD given its well-defined structure. TSD may occur in an anterograde direction (optic neuropathy causing degeneration in the posterior visual pathway including the optic radiations and occipital gray matter) and/or retrograde direction (posterior visual pathway lesions causing retinal degeneration). In the current review, we discuss evidence supporting the presence of anterograde and retrograde TSD in the visual system in MS.
- Subjects
VISUAL pathways; MULTIPLE sclerosis; RETINAL degeneration; NEURODEGENERATION; GRAY matter (Nerve tissue)
- Publication
Eye & Brain, 2023, Vol 15, p153
- ISSN
1179-2744
- Publication type
Article
- DOI
10.2147/EB.S389632