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- Title
Liver functional volumetry for portal vein embolization using a newly developed Tc-galactosyl human serum albumin scintigraphy SPECT-computed tomography fusion system.
- Authors
Beppu, Toru; Hayashi, Hiromitsu; Okabe, Hirohisa; Masuda, Toshiro; Mima, Kosuke; Otao, Ryu; Chikamoto, Akira; Doi, Koichi; Ishiko, Takatoshi; Takamori, Hiroshi; Yoshida, Morikatsu; Shiraishi, Shinya; Yamashita, Yasuyuki; Baba, Hideo
- Abstract
Background: We developed a new combined Tc-galactosyl human serum albumin (GSA) scintigraphy single-photon emission computed tomography (SPECT)/CT system to evaluate the changes in functional liver volume with portal vein embolization (PVE). Methods: We performed a prospective analysis of 25 patients treated with right PVE, and evaluated their functional liver volume perioperatively with a Tc-GSA scintigraphy SPECT-CT fusion system. The percentage of the non-tumorous remnant liver volume (%LV) and the percentage of functional remnant liver volume (%FLV) were estimated by using the following calculations: (future remnant volume − tumor volume)/(total liver volume − tumor volume) and functional future remnant liver volume/functional total liver volume, respectively. Results: Before PVE, the correlation was strongly significant between %LV and %FLV of the non-embolized liver, and the data were nearly equal (the regression coefficient was 1.005, P < 0.0001). In contrast, after PVE, there was a significant correlation between %LV and %FLV ( P < 0.0001), but the regression coefficient was 1.192. The % LV increased significantly, from 38.1 to 52.0%, and the increment was 13.9% ( P < 0.0005). The %FLV was also increased significantly, from 36.6 to 58.0%, and the increment was 21.4% ( P < 0.0001). The increment was 7.5% greater for the %FLV compared to that of the %LV ( P < 0.001). Conclusions: The Tc-GSA scintigraphy SPECT-CT fusion system can estimate the correct functional liver volume and is useful in comparison with conventional CT volumetry.
- Subjects
PORTAL vein; THERAPEUTIC embolization; LIVER function tests; SINGLE-photon emission computed tomography; POSITRON emission tomography; SERUM albumin; LONGITUDINAL method
- Publication
Journal of Gastroenterology, 2011, Vol 46, Issue 7, p938
- ISSN
0944-1174
- Publication type
Article
- DOI
10.1007/s00535-011-0406-x