We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Upregulated MicroRNA-185-3p Inhibits the Development of Hyperlipidemia in Rats.
- Authors
Zhao, Hua; Li, Yanbing
- Abstract
Introduction: MicroRNA (miR)-185-3p plays a role in multiple types of cancers, while its underlying function remains obscure in hyperlipidemia. This research was conducted to unravel its function in hyperlipidemia development via modulating mastermind-like 1 (MAML1). Methods: The hyperlipidemia rat model was established by feeding with high-fat diet. miR-185-3p and MAML1 levels in hyperlipidemia rats were detected. Adenoviral vectors altering miR-185-3p and MAML1 levels were injected into hyperlipidemia rats to examine the levels of serum lipids, oxidative stress, inflammatory cytokine, lipid accumulation, and cellular morphology in liver tissues of hyperlipidemia rats. The targeting relation between miR-185-3p and MAML1 was manifested. Results: miR-185-3p expressed at a low level, while MAML1 expressed at a high level in hyperlipidemia rats. miR-185-3p overexpression or MAML1 silencing reduced levels of serum lipids, mitigated oxidative stress and inflammatory response, and relieved lipid accumulation and pathological morphology in liver tissues in hyperlipidemia rats, while upregulated MAML1 reversed the effects of augmented miR-185-3p in hyperlipidemia rats. Mechanically, miR-185-3p targeted MAML1. Conclusion: Upregulated miR-185-3p represses hyperlipidemia development via modulating MAML1 expression. This research provides novel therapeutic candidates for the treatment of hyperlipidemia.
- Subjects
HYPERLIPIDEMIA; BLOOD lipids; HIGH-fat diet; RATS; OXIDATIVE stress
- Publication
Kidney & Blood Pressure Research, 2023, Vol 48, Issue 1, p35
- ISSN
1420-4096
- Publication type
Article
- DOI
10.1159/000526643