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- Title
Renal Function in Patients Treated with Cinacalcet for Persistent Hyperparathyroidism after Kidney Transplantation.
- Authors
Henschkowski, Jana; Bischoff-Ferrari, Heike A.; Wüthrich, Rudolf P.; Serra, Andreas L.
- Abstract
Background and Aim: Cinacalcet effectively reduces calcium in patients with persistent hyperparathyroidism (HPT) after kidney transplantation. We aimed to assess the association of cinacalcet with a decrease in renal function based on a meta-analysis of observational studies in kidney transplant patients with persistent HPT. Method: Meta-analysis of observational studies, no randomized controlled studies were available. We calculated the mean difference between renal function before cinacalcet and at 3 months on cinacalcet treatment for each study. Pooled analyses are based on random effects models. Results: Pooling the studies on kidney transplant patients with persistent HPT (8 studies, n = 115), we found a significant reduction in renal function (p = 0.008). The effect size was 5 μmol/l (p < 0.0001) when pooling the 7 studies where serum creatinine levels were reported. Meta-regression analysis revealed that there was an association between renal function and the amount of calcium reduction under treatment with cinacalcet. A higher delta change in serum calcium levels was associated with a decrease in renal function at 3 months of cinacalcet treatment. Conclusion: Cinacalcet treatment was associated with a decline of renal function in kidney transplant recipients with persistent HPT. Our meta-analysis underscores the need for frequent monitoring of creatinine and calcium levels during cinacalcet treatment. Copyright © 2011 S. Karger AG, Basel
- Subjects
HYPERPARATHYROIDISM treatment; KIDNEY transplantation; RENAL pharmacology; DRUG efficacy; CALCIUM
- Publication
Kidney & Blood Pressure Research, 2011, Vol 34, Issue 2, p97
- ISSN
1420-4096
- Publication type
Article
- DOI
10.1159/000323902