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- Title
Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia.
- Authors
Berglund, Eric D; Liu, Tiemin; Kong, Xingxing; Sohn, Jong-Woo; Vong, Linh; Deng, Zhuo; Lee, Charlotte E; Lee, Syann; Williams, Kevin W; Olson, David P; Scherer, Philipp E; Lowell, Bradford B; Elmquist, Joel K
- Abstract
Whether melanocortin 4 receptors (MC4Rs) in extra-hypothalamic neurons, including cholinergic autonomic pre-ganglionic neurons, are required to control energy and glucose homeostasis is unclear. We found that MC4Rs in sympathetic, but not parasympathetic, pre-ganglionic neurons were required to regulate energy expenditure and body weight, including thermogenic responses to diet and cold exposure and 'beiging' of white adipose tissue. Deletion of Mc4r genes in both sympathetic and parasympathetic cholinergic neurons impaired glucose homeostasis.
- Subjects
MELANOCORTIN receptors; NEURONS; BODY temperature regulation; GLYCEMIC index; CHOLINERGIC receptors; WHITE adipose tissue; HOMEOSTASIS
- Publication
Nature Neuroscience, 2014, Vol 17, Issue 7, p911
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.3737