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- Title
A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration.
- Authors
Miller, Bradley R.; Press, Craig; Daniels, Richard W.; Sasaki, Yo; Milbrandt, Jeffrey; DiAntonio, Aaron
- Abstract
Axon degeneration underlies many common neurological disorders, but the signaling pathways that orchestrate axon degeneration are unknown. We found that dual leucine kinase promoted degeneration of severed axons in Drosophila and mice, and that its target, c-Jun N-terminal kinase, promoted degeneration locally in axons as they committed to degenerate. This pathway also promoted degeneration after chemotherapy exposure and may be a component of a general axon self-destruction program.
- Subjects
NEURODEGENERATION; AXONS; LEUCINE; DROSOPHILA; DRUG therapy
- Publication
Nature Neuroscience, 2009, Vol 12, Issue 4, p387
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/nn.2290