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- Title
Brain structural and functional recovery following initiation of combination antiretroviral therapy.
- Authors
Becker, James; Cuesta, Pablo; Fabrizio, Melissa; Sudre, Gustavo; Vergis, Emanuel; Douaihy, Antoine; Bajo, Ricardo; Schubert, Allie; Lopez, Oscar; Parkkonen, Lauri; Maestu, Fernando; Bagic, Anto
- Abstract
NeuroAIDS persists in the era of combination antiretroviral therapies. We describe here the recovery of brain structure and function following 6 months of therapy in a treatment-naive patient presenting with HIV-associated dementia. The patient's neuropsychological test performance improved and his total brain volume increased by more than 5 %. Neuronal functional connectivity measured by magnetoencephalography changed from a pattern identical to that observed in other HIV-infected individuals to one that was indistinguishable from that of uninfected control subjects. These data suggest that at least some of the effects of HIV on the brain can be fully reversed with treatment.
- Subjects
ANTIRETROVIRAL agents; NEUROPSYCHOLOGICAL tests; HIV-positive persons; BRAIN anatomy; MAGNETOENCEPHALOGRAPHY; COMBINATION drug therapy
- Publication
Journal of NeuroVirology, 2012, Vol 18, Issue 5, p423
- ISSN
1355-0284
- Publication type
Article
- DOI
10.1007/s13365-012-0115-0