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- Title
Evaluation of the Association Between Coronary Artery Aneurysms and Concomitant Infection in Patients With Kawasaki Disease.
- Authors
Liu, Jie; Su, Danyan; Qin, Suyuan; Ye, Bingbing; Wang, Baofeng; Pang, Yusheng
- Abstract
We analyzed the relationship between recovery from coronary artery aneurysms (CAAs) and concurrent infections in patients with Kawasaki disease (KD). The estimated median time of aneurysm persistence between patients with and without infections was compared using Kaplan-Meier survival analyses. Risk factors associated with persistent CAAs at 2 years were identified using multivariable analyses. Co-infection was confirmed in 20.5% (106/518) of patients diagnosed with KD. No significant differences regarding treatment or coronary artery outcome were identified between patients with and without infections. The estimated median time of aneurysm persistence was higher in the co-infected group (9 vs. 6 months). A maximum Z -score ≥ 4.00 at 1 month had 78% sensitivity and 83% specificity in predicting CAAs without recovery within 1 year of onset, whereas the predictability was higher within 2 years of onset, with a Z -score ≥ 4.88 (sensitivity, 92%; specificity, 91%). Concomitant infections did not affect the response to treatment or coronary artery outcomes in patients with KD.
- Subjects
ANEURYSMS; RISK assessment; INTRAVENOUS immunoglobulins; CORONARY disease; MULTIVARIATE analysis; DESCRIPTIVE statistics; KAPLAN-Meier estimator; CONVALESCENCE; MUCOCUTANEOUS lymph node syndrome; MIXED infections; SENSITIVITY &; specificity (Statistics)
- Publication
Clinical Pediatrics, 2024, Vol 63, Issue 6, p785
- ISSN
0009-9228
- Publication type
Article
- DOI
10.1177/00099228231196526