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- Title
Influence of Withania somnifera on obsessive compulsive disorder in mice
- Authors
Kaurav, Bhanu PS; Wanjari, Manish M; Chandekar, Amol; Chauhan, Nagendra Singh; Upmanyu, Neeraj
- Abstract
Abstract: Objective: To study the influence of methanolic and aqueous extract of Withania somnifera (W. somnifera) root on the marble-burying behavior of mice a well-accepted model of obsessive compulsive behavior. Methods: Mice were divided in different groups (n = 6). Fluoxetine (5, 10, 15 mg/kg), (10, 25, 50, 100 mg/kg) and methanolic extract W. somnifera (MEWS) (10, 25, 50, 100 mg/kg) were administered i.p. 30 min. prior to the assessment of marble burying behavior and locomotor activity. The control group received vehicle of the extract. Results: Administration of aqueous extracts W. somnifera (AEWS) and MEWS (50 mg/kg) successively decreaesed the marble burying behavior activity without affecting motor activity. This effect of AEWS and MEWS was comparable to standard fluoxetine, ritanserin and parachlorophenylalanine. Conclusions: W. somnifera extract is effective in treating obsessive compulsive disorder.
- Subjects
WITHANIA somnifera; MENTAL health services; OBSESSIVE-compulsive disorder; LABORATORY mice; FLUOXETINE; CHLOROPHENYLALANINE; MICE behavior; ANIMAL locomotion
- Publication
Asian Pacific Journal of Tropical Medicine, 2012, Vol 5, Issue 5, p380
- ISSN
1995-7645
- Publication type
Article
- DOI
10.1016/S1995-7645(12)60063-7