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- Title
PHYTOCHEMICAL INVESTIGATION AND PHARMACOLOGICAL EVALUATION OF VARIOUS EXTRACTS OF SEEDS OF BRASSICA CAMPESTRIS LINN.
- Authors
Bidkar, Abhijit A.; Gujar, Kishor N.; Shrungarkar, Anuj K.; Parmar, Prakash S.; Aswar, Manoj K.
- Abstract
The objective of the study was to evaluate the anticonvulsant activity of the various extracts of seeds of Brassica campestris. The various extracts included Aqueous extract (AQBC), Ethanolic extract (ELBC), Benzene extract (BZBC), Chloroform extract (CLBC), Ethyl acetate extract (EABC), Aqueous ethanolic extract (AEBC) were used. The anticonvulsant activity was assessed using the Pentylenetetrazole (PTZ) induced convulsions model in mice (60 mg/kg i.p). ELBC shows 100% protection of the mice against PTZ induced convulsions. The CLBC and BZBC significantly (p<0.005) reduced the duration of convulsions in mice but prevents mortality in 50% of mice. The AQBC showed no significant activity against PTZ induced convulsions. The EABC and AEBC showed less significant activity. The observations suggests that the ELBC possesses anticonvulsant activity against PTZ induced convulsions.
- Subjects
PHYTOCHEMICALS; TURNIPS; PLANT extracts; ETHANOL; CHLOROFORM; ANTICONVULSANTS; LABORATORY mice; BENZENE
- Publication
International Journal of Pharmacology & Biological Sciences, 2011, Vol 5, Issue 3, p27
- ISSN
0973-6808
- Publication type
Article