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- Title
Expression of miR-199a-3p in human adipocytes is regulated by free fatty acids and adipokines.
- Authors
NAN GU; LIANGHUI YOU; CHUNMEI SHI; LEI YANG; LINGXIA PANG; XIANWEI CUI; CHENBO JI; WEN ZHENG; XIRONG GUO
- Abstract
Obesity is associated with a notable risk for disease, including risk of cardiovascular disorders, type 2 diabetes mellitus (T2DM) and hypertension. Adipose tissue modulates the metabolism by releasing free fatty acids (FFAs) and adipokines, including leptin, resistin, tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6). Altered secretion patterns of FFAs and adipokines have been demonstrated to result in obesity-associated insulin resistance (IR) and inflammatory responses. MicroRNA-199a-3p (miR)-199a-3p expression is significantly induced in differentiated human adipose-derived mesenchymal stem cells and indicates the association with T2DM. However, the association between miR-199a-3p levels in adipocytes and obesity-associated IR, as well as inflammatory responses remains to be elucidated. The present study observed an elevation of miR-199a-3p expression level in mature human adipocytes (visceral) compared with pre-adipocytes. In addition, miR-199a-3p expression was higher in visceral adipose deposits from obese subjects. FFA, TNF-α, IL-6 and leptin significantly induced miR-199a-3p expression in mature human adipocytes, while resistin had the opposite effect. miR-199a-3p may represent a factor in the modulation of obesity-associated IR and inflammatory responses.
- Subjects
OBESITY &; society; PHYSIOLOGICAL effects of leptin; INTERLEUKINS; FAT cells; INSULIN resistance; PHYSIOLOGY
- Publication
Molecular Medicine Reports, 2016, Vol 14, Issue 2, p1180
- ISSN
1791-2997
- Publication type
Article
- DOI
10.3892/mmr.2016.5379