<bold>Clinical Question: </bold>What medical therapies are associated with greatest efficacy and fewest adverse events for treating hirsutism?<bold>Bottom Line: </bold>Oral contraceptive pills (OCPs) have been associated with improvement for mild hirsutism, as has flutamide (250 mg) twice daily and spironolactone for more severe cases. Finasteride and gonadotropin-releasing analogues are associated with inconsistent results and metformin is not associated with benefit.