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- Title
Dietary Choline Intake during Pregnancy and PEMT rs7946 Polymorphism on Risk of Preterm Birth: A Case-Control Study.
- Authors
Zhu, Jie; Liu, Yu-Hong; He, Xiang-Long; Kohlmeier, Martin; Zhou, Li-Li; Shen, Li-Wei; Yi, Xin-xuan; Tang, Qing-Ya; Cai, Wei; Wang, Bei
- Abstract
Introduction and Aims: Choline-metabolizing genetic variation may interact with choline intake on fetal programming and pregnancy outcome. This case-control study aims to explore the association of maternal choline consumption and phosphatidylethanolamine N-methyltransferase (PEMT) gene polymorphism rs7946 with preterm birth risk. Methods: 145 Han Chinese women with preterm delivery and 157 Han Chinese women with term delivery were recruited in Shanghai. Dietary choline intake during pregnancy was assessed using a validated food frequency questionnaire. Additionally, DNA samples were genotyped for PEMT rs7946 (G5465A) with plasma homocysteine (Hcy) levels measured. Results: Compared with the lowest quartile of choline intake, women within the highest consumption quartile had adjusted odds ratio (aOR) for preterm birth of 0.48 (95% confidence interval, CI [0.24, 0.95]). There was a significant interaction between maternal choline intake and PEMT rs7946 (p for interaction = 0.04), where the AA genotype carriers who consumed the energy-adjusted choline <255.01 mg/day had aOR for preterm birth of 3.75 (95% CI [1.24, 11.35]), compared to those with GG genotype and choline intake >255.01 mg/day during pregnancy. Additionally, the greatest elevated plasma Hcy was found in the cases with AA genotype and choline consumption <255.01 mg/day (p < 0.001). Conclusion: The AA genotype of PEMT rs7946 may be associated with increased preterm birth in these Han Chinese women with low choline intake during pregnancy.
- Subjects
CHINA; DNA analysis; HOMOCYSTEINE; PREMATURE infants; CONFIDENCE intervals; INGESTION; GENETIC polymorphisms; CASE-control method; NUTRITIONAL requirements; CHOLINE; RISK assessment; QUESTIONNAIRES; GENOTYPES; ODDS ratio; PREGNANCY
- Publication
Annals of Nutrition & Metabolism, 2020, Vol 76, Issue 6, p431
- ISSN
0250-6807
- Publication type
Article
- DOI
10.1159/000507472