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- Title
Interleukin-18 Antagonism Improved Histopathological Conditions of Malaria Infection in Mice.
- Authors
JABBARZARE, Marzieh; Voon Kin CHIN; TALIB, Herni; Mun Fei YAM; Khadijah, Siti; HASSAN, ADAM Haniza; MAJID, Roslaini ABDUL; MAT TAIB, Che Norma; MOHD MOKLAS, Mohamad Aris; HIDAYAT, Mohamad TAUFIK; SIDEK, Hasidah MOHD; BASIR, Rusliza
- Abstract
Background: Interleukin 18 (IL-18) exerts pleiotropic roles in many inflammatory-related diseases including parasitic infection. Previous studies have demonstrated the promising therapeutic potential of modulating IL-18 bioactivity in various pathological conditions. However, its involvement during malaria infection has yet to be established. In this study, we demonstrated the effect of modulating IL-18 on the histopathological conditions of malaria infected mice. Methods: Plasmodium berghei ANKA infection in male ICR mice was used as a model for malaria infection. Modulation of IL-18 release was carried out by treatment of malarial mice with recombinant mouse IL-18 (rmIL-18) and recombinant mouse IL-18 Fc chimera (rmIL-18Fc) intravenously. Histopathological study and analysis were performed on major organs including brain, liver, spleen, lungs and kidney. Results: Treatment with rmIL-18Fc resulted in significant improvements on the histopathological conditions of the organs in malaria-infected mice. Conclusion: IL-18 is an important mediator of malaria pathogenesis and targeting IL-18 could prove beneficial in malaria-infected host.
- Subjects
INTERLEUKIN-18; PARASITIC diseases; MALARIA; LABORATORY mice; PLASMODIUM berghei
- Publication
Iranian Journal of Parasitology, 2015, Vol 10, Issue 3, p389
- ISSN
1735-7020
- Publication type
Article