We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Circulating tumour cells in breast cancer.
- Authors
Krawczyk, Natalia; Banys, Malgorzata; Hartkopf, Andreas; Hagenbeck, Carsten; Melcher, Carola; Fehm, Tanja
- Abstract
Evaluation of isolated tumour cells in bone marrow (BM) and peripheral blood has become a major focus of translational cancer research. The presence of disseminated tumour cells in BM is a common phenomenon observed in 30-40% of primary breast cancer patients and independently predicts reduced clinical outcome. The detection of circulating tumour cells (CTCs) in blood might become a desired alternative to the invasive and painful BM biopsy. Recent clinical trials confirmed the feasibility of CTC detection as a robust and reproducible parameter for prognostication in both adjuvant and metastatic setting. The characterisation of CTCs might become an important biomarker for therapy monitoring and help to identify specific targets for novel therapeutic strategies.
- Subjects
CANCER cells; BREAST cancer; FEASIBILITY studies; BIOMARKERS; THERAPEUTICS
- Publication
Ecancermedicalscience, 2013, Vol 7, Issue 334-360, p1
- ISSN
1754-6605
- Publication type
Article
- DOI
10.3332/ecancer.2013.352