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- Title
Paraneoplastic hypercalcemia in clear cell ovarian adenocarcinoma.
- Authors
Lewin, S.; Dezube, D.; Guddati, A. K.; Mittal, K.; Muggia, F.; Klein, Paula
- Abstract
Background: Hypercalcemia has been reported in association with a number of malignancies, but it is an unusual manifestation of ovarian cancer. This finding at presentation (possibly aggravated by oral calcium intake) led to discovery of a clear cell carcinoma of the ovary. The implications and pathophysiology of this association are reviewed. Case report: Following presentation with abdominal symptoms, this premenopausal woman was found to have bilateral adnexal masses and hypercalcemia. Her parathormone-related polypeptide was found to be elevated. After surgery and staging, she received adjuvant carboplatin and paclitaxel (later substituted by docetaxel). She has done well on her long-term follow-up. Conclusions: This rare paraneoplastic manifestation of ovarian cancer may be associated with long-term survival if discovered at an early stage. In this instance, further benefit may have been obtained from adjuvant platinum-based chemotherapy.
- Subjects
HYPERCALCEMIA; OVARIAN cancer; ADENOCARCINOMA; CALCIUM metabolism disorders; PARANEOPLASTIC syndromes
- Publication
Ecancermedicalscience, 2012, Vol 6, Issue 271-285, p1
- ISSN
1754-6605
- Publication type
Case Study
- DOI
10.3332/ecancer.2012.271